Our Science

Publications

Our Science

FDA
National Cancer institute
NINDS
Blood Brain Barrier
Brain Tumors
Duke Health
Indenoisoquinoline drug compounds
Indenoisoquinoline drug compounds
purdue
Gibson Oncology
FDA

1. Scientific Information Requiring a Confidential Agreement 

  • There is important scientific information on LMP400 and LMP744f in GBM and multiple other brain tumors in our approved FDA Orphan Drug Designation filings which can be obtained under a confidentiality agreement.
  • There are extensive studies done on LMP744 and LMP400 in brain tumors by both the NIH and Gibson Oncology, which are awaiting publication and can be viewed under a confidentiality agreement.

Our Scientific Publications

4. Indenos cross the Blood Brain Barrier and Maintain High Levels in the Brain for Many Hours

Blood Brain Barrier

7. Potential Uses of Indenos in Other Tumors

  • PTEN Deficient Tumors, especially those Resistant to Irinotecan
  • Indenos Work when Tumors Develop Irinotecan Resistance 
  • Breast and Ovarian Tumors
  • Colorectal, Pancreatic, and Prostate Carcinomas
  • Endocrine Tumors and Pheochromocytomas 
  • Ewing Sarcoma 

8. Indenos Overview, Mechanisms of Action, & PK

  • Mechanisms of Action
  • Top1 Inhibition
  • Potential Biomarkers